Functional genomics of human brain development and implications for autism spectrum disorders

Functional Genomics Studies of Human Brain Development and Implications for Autism Spectrum Disorder

Structural and Functional Brain Imaging in Autism Spectrum Disorders

Autism Spectrum Disorders: Insights from Genomics

The field of genetics has made considerable scientific progress in the past several years and continues to evolve at a rapid pace. This progress parallels developments in genom‐ ic technology, where instrumentation and methodology are becoming increasingly so‐ phisticated and cost-effective. Here, we review recent developments in understanding autism spectrum disorder (ASD) from a genomics pers...

C1q as a Regulator of Brain Development: Implications for Autism Spectrum Disorders

Autism spectrum disorders (ASDs) represents a heterogeneous group of neurodevelopmental disorders with similar core features of social and communication impairments, restricted interests and repetitive behaviors. Early synaptic dysfunction due to neuroinflammatory insults may underpin the pathogenesis of abnormal brain development in some of individuals with ASDs. As a critical component of the...

Atypical functional brain connectivity during rest in autism spectrum disorders.

OBJECTIVE Connectivity atypicalities in autism spectrum disorders (ASD) have been extensively proposed. The default mode network (DMN) is critical in this study, given the insight it provides for long-distance connectivity, and the importance of regions in this network for introspection and social emotion processing, areas affected in ASD. However, study of this network has largely been limited...